HCYP1B1-IN-2

HCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM[1].

Product Specifications

CAS Number

[3043683-33-3]

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor; Cytochrome P450

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcyp1b1-in-2.html

Smiles

O=C(N(CC1=CN=CN=C1)C2=O)C3=CC=C(Br)C4=CC=CC2=C43

Molecular Formula

C17H10BrN3O2

Molecular Weight

368.18

References & Citations

[1]Wei Y, et al. Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors. Bioorg Med Chem Lett. 2024 Jul 15;107:129776.