Lavendustin A

Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2].

Product Specifications

CAS Number

[125697-92-9]

Product Name Alternative

RG-14355

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Lavendustin_A.html

Concentration

10mM

Purity

98.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O

Molecular Formula

C21H19NO6

Molecular Weight

381.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Onoda T, et, al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52 (6) :1252-7. |[2]Hu DE, et, al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114 (2) :262-8. |[3]Whitehead SA, et, al. Protein tyrosine kinase activity of lavendustin A and the phytoestrogen genistein on progesterone synthesis in cultured rat ovarian cells. Fertil Steril. 2000 Mar;73 (3) :613-9.