D[LEU4, LYS8]-VP

D[LEU4, LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4, LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

Product Specifications

CAS Number

[42061-33-6]

UNSPSC

12352209

Target

Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-leu4-lys8-vp.html

Solubility

H2O

Smiles

[{Mpa}-YFLNCPKG-NH2(Disulfidebridge:Mpa1-Cys6)]

Molecular Formula

C47H67N11O11S2

Molecular Weight

1026.23

References & Citations

[1]Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148 (9) : 4136-46.|[2]Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V (1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50 (4) : 835-47.