Lenalidomide-C5-amido-Boc

Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[2138441-25-3]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenalidomide-c5-amido-boc.html

Purity

95.10

Solubility

DMSO : 90 mg/mL (ultrasonic)

Smiles

O=C(OC(C)(C)C)NCCCCCC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O

Molecular Formula

C23H31N3O5

Molecular Weight

429.51

References & Citations

[1]Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.|[2]Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.