Ki8751
Ki8751 is a potent VEGFR2 inhibitor with an IC50 of 0.9 nM.
Product Specifications
CAS Number
[228559-41-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ki8751.html
Purity
99.76
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C(F)=C3)NC(NC4=CC=C(C=C4F)F)=O
Molecular Formula
C24H18F3N3O4
Molecular Weight
469.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Kubo K, et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4- (4-quinolyloxy) phenyl}ureas. J Med Chem, 2005, 48 (5), 1359-1366.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Available Sizes
Curated Selection
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