Jingzhaotoxin-XII (TFA)
Jingzhaotoxin-XII (JzTx-XII) TFA is a specific Kv4.1 channel inhibitor with an IC50 of 0.363 μM. Jingzhaotoxin-XII TFA interacts with the channels by modifying the gating behavior[1].
Product Specifications
Product Name Alternative
JzTx-XII (TFA)
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jingzhaotoxin-xii-tfa.html
Purity
96.23
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C([C@@H](N)CC1=CC=C(O)C=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(N)=O)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CO)=O)CC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CC(C)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CC8=CNC9=CC=CC=C89)=O)CCSC)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5C(C)C)=O)CC%12=CC=C(O)C=C%12)=O)=O)CCC(O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C161H227N41O44S7.xC2HF3O2
Molecular Weight
3665.23 (free base)
References & Citations
[1]Yuan C, et al. Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels. Toxicon. 2007 Oct;50 (5) :646-52.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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