Proxyphylline
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator[1].
Product Specifications
CAS Number
603-00-9
UNSPSC
12352005
Hazard Statement
H302
Target
Adenosine Receptor; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Proxyphylline.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1C)N(C)C2=C(N(CC(O)C)C=N2)C1=O
Molecular Formula
C10H14N4O3
Molecular Weight
238.25
Precautions
H302
References & Citations
[1]Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27 (5) :709-20.|[2]Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33 (10) :1450-4.|[3]Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65 (1) :20-7.|[4]Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh) . 1982 Sep;51 (3) :250-2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
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