Anti-Mouse IL-1b Antibody (B122)

Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655) . Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure[1][2][3].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

Ferroptosis; Interleukin Related; Reactive Oxygen Species (ROS)

Type

Inhibitory Antibodies

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/anti-mouse-il-1b-antibody-b122.html

Purity

Solubility

H2O

Smiles

[Anti-MouseIL-1bAntibody(B122)]

Molecular Weight

(150 kDa)

References & Citations

[1]Zhou R, et al. Sulfasalazine combined with anti-IL-1β mAb induces ferroptosis and immune modulation in oral squamous cell carcinoma. Cell Mol Life Sci. 2025 May 28;82 (1) :216.|[2]Chen Z, et al. A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression. J Clin Invest. 2023 Nov 15;133 (22) :e163802.|[3]Agrawal V, et al. Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF. Circ Res. 2023 Nov 10;133 (11) :885-898.