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N-Boc-trans-4-fluoro-L-proline

N-Boc-trans-4-fluoro-L-proline is a non-natural amino acid substitute used to construct monoclonal antibodies that specifically target the seed conformation of tau protein[1].

Product Specifications

CAS Number

203866-14-2

UNSPSC

12352209

Hazard Statement

H315, H319, H335

Target

Drug Intermediate

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-boc-trans-4-fluoro-l-proline.html

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C(O)=O)C[C@@H](F)C1)OC(C)(C)C

Molecular Formula

C10H16FNO4

Molecular Weight

233.24

Precautions

H315, H319, H335

References & Citations

[1]Hitt BD, et al. Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds. J Biol Chem. 2023 Nov;299 (11) :105252.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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