Moronic acid

Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC50 value of [1][2][3].

Product Specifications

CAS Number

[6713-27-5]

Product Name Alternative

(+) -Moronic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

HIV; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/moronic-acid.html

Purity

98.6

Smiles

C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)([H])C5=CC(C)(C)CC[C@@]5(CC3)C(O)=O)C

Molecular Formula

C30H46O3

Molecular Weight

454.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Ito J, et al. Anti-AIDS agents. 48. (1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod. 2001 Oct;64 (10) :1278-81.|[2]Shuiliang Ruan, et al. Moronic acid improves intestinal inflammation in mice with chronic colitis by inhibiting intestinal macrophage polarization. J Biochem Mol Toxicol. 2022 Nov;36 (11) :e23188. |[3]M Kurokawa, et al. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo. J Pharmacol Exp Ther. 1999 Apr;289 (1) :72-8.