TIC10g
TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC50 is 14.5 μM and 6.5 μM) and human B lymphocytes (IC50 is 7.69 μM and 11.5 μM) . TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis [1].
Product Specifications
CAS Number
754998-88-4
UNSPSC
12352005
Target
NF-κB; p38 MAPK; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tic10g.html
Smiles
CN1C(C2=CC=C3C(OCO3)=C2)=CN=C1NCC4=C(OC)C=C(OC)C=C4
Molecular Formula
C20H21N3O4
Molecular Weight
367.40
References & Citations
[1]Haseeb M, et al., Discovery of Novel Small Molecule Dual Inhibitor Targeting Toll-Like Receptors 7 and 9. J Chem Inf Model. 2024 Jun 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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