UE2343

UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease[1].

Product Specifications

CAS Number

[1346013-80-6]

UNSPSC

12352005

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ue2343.html

Smiles

O=C(C1=CSC(C2=CNN=C2)=C1)N3[C@]4([H])C[C@@](C[C@@]3([H])CC4)(C5=NC=CC=N5)O

Molecular Formula

C19H19N5O2S

Molecular Weight

381.45

References & Citations

[1]Webster S P, et al. Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™) [J]. British Journal of Pharmacology, 2017, 174 (5) : 396-408.