UE2343
UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease[1].
Product Specifications
CAS Number
1346013-80-6
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ue2343.html
Smiles
O=C(C1=CSC(C2=CNN=C2)=C1)N3[C@]4([H])C[C@@](C[C@@]3([H])CC4)(C5=NC=CC=N5)O
Molecular Formula
C19H19N5O2S
Molecular Weight
381.45
References & Citations
[1]Webster S P, et al. Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™) [J]. British Journal of Pharmacology, 2017, 174 (5) : 396-408.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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