Hematoxylin

Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 μM.

Product Specifications

CAS Number

[517-28-2]

Product Name Alternative

Natural Black 1; Haematoxylin

UNSPSC

12171500

Hazard Statement

H319, H402

Target

Amyloid-β

Type

Dye Reagents

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Hematoxylin.html

Concentration

10mM

Purity

99.40

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic)

Smiles

OC1=CC=C([C@]2([H])[C@](CC3=C2C=C(O)C(O)=C3)(O)CO4)C4=C1O

Molecular Formula

C16H14O6

Molecular Weight

302.28

Precautions

H319, H402

References & Citations

[1]M Titford. The long history of hematoxylin. Biotech Histochem. Mar-Apr 2005;80 (2) :73-8.|[2]Yilong Tu, et al. Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity. J Phys Chem B. 2016 Nov 10;120 (44) :11360-11368.|[3]Ada T Feldman, et al. Tissue processing and hematoxylin and eosin staining. Methods Mol Biol. 2014;1180:31-43.|[4]Robert D Cardiff, et al. Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb Protoc. 2014 Jun 2;2014 (6) :655-8.