Ponicidin
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].
Product Specifications
CAS Number
[52617-37-5]
Product Name Alternative
Rubescensine B
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ponicidin.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@]12[C@]3(C4=O)[C@]5([H])C6([C@](O[C@@]3([H])[C@](CC5)([H])C4=C)([H])O2)[C@](C(C)(CC[C@@H]6O)C)([H])[C@@H]1O
Molecular Formula
C20H26O6
Molecular Weight
362.42
Precautions
H302
References & Citations
[1]Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16 (1) :1576-89.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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