SKF 38393 (hydrochloride)

SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

Product Specifications

CAS Number

[62717-42-4]

Product Name Alternative

(±) -SKF-38393 hydrochloride; SKF-38393A

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SKF-38393-hydrochloride.html

Purity

99.49

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl

Molecular Formula

C16H18ClNO2

Molecular Weight

291.77

Precautions

H315, H319, H335

References & Citations

[1]Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7 (1) :213-222.|[2]Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84 (1) :257-64.|[3]Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892 (2) :241-7.|[4]Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94 (4) :1063-70.