Upadacitinib-15N, d2
Upadacitinib-15N, d2 (ABT-494-15N, d2) is the deuterium-labeled Upadacitinib. Upadacitinib-15N, d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib-15N, d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-15N, d2 (ABT-494) can be used for several autoimmune disorders research[1][2].
Product Specifications
Product Name Alternative
ABT-494-15N, d2
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Others
Purity
99.99
Solubility
10 mM in DMSO|DMSO : 100mg/mL (ultrasonic)
Smiles
CC[C@H]1[C@H](CN(C1)C([15NH]C([2H])([2H])C(F)(F)F)=O)C2=CN=C3C=NC(NC=C4)=C4N23
Molecular Formula
C17H17D2F3N5 15NO
Molecular Weight
383.37
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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