Fomesafen

Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO) . Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards[1][2][3][4][5][6].

Product Specifications

CAS Number

[72178-02-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Herbicide; Protoporphyrinogen IX oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fomesafen.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NS(=O)(C)=O)C1=CC(OC2=CC=C(C(F)(F)F)C=C2Cl)=CC=C1[N+]([O-])=O

Molecular Formula

C15H10ClF3N2O6S

Molecular Weight

438.76

Precautions

H302

References & Citations

[1]Li-Xia Zhao, et al. Novel Thiazole Phenoxypyridine Derivatives Protect Maize From Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen. Biomolecules. 2019 Sep 20;9 (10) :514.|[2]MACAR O, et al. FOMESAFEN-INDUCED MERISTEMATIC CELL DAMAGES IN ALLIUM CEPA L. (ONION) [J]. |[3]Xu Z, et al. Effect of fomesafen on the embryonic development of zebrafish. Chemosphere. 2020 Nov;259:127380.|[4]Krijt J, et al. Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice. Toxicol Appl Pharmacol. 2003 May 15;189 (1) :28-38. |[5]Krijt J, et al. Liver preneoplastic changes in mice treated with the herbicide fomesafen. Hum Exp Toxicol. 1999 May;18 (5) :338-44. |[6]Zhang Q, et al. Oxidative stress and lipid peroxidation in the earthworm Eisenia fetida induced by low doses of fomesafen. Environ Sci Pollut Res Int. 2013 Jan;20 (1) :201-8.