Paynantheine
Paynantheine is an alkaloid with antinociceptive activity, which is found in Mitragyna speciosa. Paynantheine is also a 5-HT1AR and 5-HT2BR agonist that induces lower lip retraction and antinociception in rats[1][2].
Product Specifications
CAS Number
4697-66-9
UNSPSC
12352005
Target
5-HT Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/paynantheine.html
Smiles
COC1=C2C3=C(NC2=CC=C1)[C@@]4([H])N(C[C@@H]([C@H](C4)/C(C(OC)=O)=C\OC)C=C)CC3
Molecular Formula
C23H28N2O4
Molecular Weight
396.48
References & Citations
[1]Philipp AA, et al. Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879 (15-16) :1049-55.|[2]León F, et al. Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. J Med Chem. 2021 Sep 23;64 (18) :13510-13523.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MLAG-3; α-1 microglobulin
Available Sizes
Frequently Asked Questions
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