Azelaprag
Azelaprag (Example 263.0) is a candidate active molecule for an Apelin receptor agonist with an EC50 of 0.32 nM for the apelin receptor[1].
Product Specifications
CAS Number
[2049980-18-7]
Product Name Alternative
AMG 986
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Azelaprag.html
Purity
99.94
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=S(NC1=NN=C(C2=CN=CC(C)=C2)N1C(C(OC)=CC=C3)=C3OC)([C@@H](C)[C@@H](C4=NC=C(C)C=N4)C)=O
Molecular Formula
C25H29N7O4S
Molecular Weight
523.61
References & Citations
[1]WO2016187308A1.|[2]Ason B, et.al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020 Apr 23;5 (8) :e132898.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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