CDK7/12-IN-1
CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively. CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth[1].
Product Specifications
CAS Number
[2654075-94-0]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk7-12-in-1.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=C(C)N=C5C=C(C)C=CN54)=C2
Molecular Formula
C25H34N8O
Molecular Weight
462.59
References & Citations
[1]Edward AINSCOW, et al. 4-[[ (7-aminopyrazolo[1,5-a]pyrimidin-5-yl) amino]methyl]piperidin-3-ol compounds and their therapeutic use. WO2021122745A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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