Human TYK2 Protein Active

<strong>Human TYK2 Protein Active</strong>_x000D_ <strong>Catalog number:</strong> B2014224_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 40 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> ‚àí20¬∞C_x000D_ <strong>Keywords:</strong> TYK2 Protein, active, 10 ¬µg_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A; GenOMICC Investigators; ISARIC4C Investigators; COVID-19 Human Genetics Initiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVID Investigators; Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Genetic mechanisms of critical illness in COVID-19 Nature. 2021 Mar;591(7848):92-98._x000D_ 2: Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mr_zek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia N Engl J Med. 2014 Sep 11;371(11):1005-15._x000D_ 3: McInnes IB, Byers NL, Higgs RE, Lee J, Macias WL, Na S, Ortmann RA, Rocha G, Rooney TP, Wehrman T, Zhang X, Zuckerman SH, Taylor PC. Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations Arthritis Res Ther. 2019 Aug 2;21(1):183._x000D_ 4: Li Z, Rotival M, Patin E, Michel F, Pellegrini S. Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage PLoS One. 2020 Jan 21;15(1):e0225289._x000D_ 5: Mallone R, Eizirik DL. Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes? Diabetologia. 2020 Oct;63(10):1999-2006._x000D_ 6: Gerstenberger BS, Banker ME, Clark JD, Dowty ME, Fensome A, Gifford R, Griffor MC, Hegen M, Hollingshead BD, Knafels JD, Lin TH, Smith JF, Vajdos FF. Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences Sci Rep. 2020 Jun 2;10(1):8974._x000D_ 7: Miyakawa Y, Oda A, Druker BJ, Ozaki K, Handa M, Ohashi H, Ikeda Y. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets Blood. 1997 Apr 15;89(8):2789-98._x000D_ 8: Revach OY, Sandler O, Samuels Y, Geiger B. Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells Cancer Res. 2019 May 15;79(10):2634-2648._x000D_ 9: Kim SS, Park SH, Lee JR, Jung JS, Suh HW. The activation of (2)-adrenergic receptor in the spinal cord lowers sepsis-induced mortality Korean J Physiol Pharmacol. 2017 Sep;21(5):495-507._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/20709027">10: Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T. IFN-_ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production Biochem Pharmacol. 2010 Dec 15;80(12):2074-86. </a>_x000D_ _x000D_ <strong>Products Related to Human TYK2 Protein Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>