Riluzole hydrochloride

Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.

Product Specifications

CAS Number

[850608-87-6]

Product Name Alternative

PK 26124 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Riluzole_hydrochloride.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)

Smiles

NC1=NC2=CC=C(OC(F)(F)F)C=C2S1.Cl

Molecular Formula

C8H6ClF3N2OS

Molecular Weight

270.66

Precautions

H302, H315, H319, H335

References & Citations

[1]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA (A) receptor function. Neuropharmacology. 2002 Feb;42 (2) :199-209.|[2]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28;11:51.