Naratuximab emtansine
Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis[1].
Product Specifications
CAS Number
1607824-64-5
Product Name Alternative
IMGN529; Debio 1562
UNSPSC
12352100
Target
Antibody-Drug Conjugates (ADCs) ; Apoptosis
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/naratuximab-emtansine.html
Purity
98.52
Solubility
10 mM in DMSO
Smiles
[Naratuximabemtansine]
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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