Glycolithocholic acid 3-sulfate (disodium)

Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9 and 66.8 μM (absence of Zn2+) and 8 and 8.7 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease[1][2][3].

Product Specifications

CAS Number

[64936-82-9]

Product Name Alternative

Glycolithocholate sulfate (disodium) ; Sulfolithocholylglycine (disodium) ; SLCG (disodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

GPR39; HIV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/glycolithocholic-acid-3-sulfate-disodium.html

Purity

99.73

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)(O[Na])=O)([H])CC3)C

Molecular Formula

C26H41NNa2O7S

Molecular Weight

557.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988) . 1989;2 (3) :264-271.|[2]I M Yousef, et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80 (2) :233-41.|[3]Zi, Zhentao; Xian, Yi; Han, Shangchen; Zhou, Enxing; Wang, Meihuang; Rao, Yi. Use of bile acids and derivatives thereof in preparation of GPR39 agonist. WO2021083336A1.