MK-3207
MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM) . MK-3207 can be used for migraine studies[1].
Product Specifications
CAS Number
957118-49-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CGRP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MK-3207.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : ≥ 150 mg/mL
Smiles
O=C1C2(NC[C@@H](C3=CC(F)=CC(F)=C3)N1CC(NC4=CC5=C(C[C@@]6(C(NC7=C6C=CC=N7)=O)C5)C=C4)=O)CCCC2
Molecular Formula
C31H29F2N5O3
Molecular Weight
557.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Salvatore CA, Moore EL, Calamari A, Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333 (1) :152-60.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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