MK-3207

MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM) . MK-3207 can be used for migraine studies[1].

Product Specifications

CAS Number

[957118-49-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CGRP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/MK-3207.html

Concentration

10mM

Purity

99.61

Solubility

DMSO : ≥ 150 mg/mL

Smiles

O=C1C2(NC[C@@H](C3=CC(F)=CC(F)=C3)N1CC(NC4=CC5=C(C[C@@]6(C(NC7=C6C=CC=N7)=O)C5)C=C4)=O)CCCC2

Molecular Formula

C31H29F2N5O3

Molecular Weight

557.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Salvatore CA, Moore EL, Calamari A, Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333 (1) :152-60.