Isoniazid (Standard)

Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

Product Specifications

CAS Number

[54-85-3]

Product Name Alternative

INH (Standard) ; Isonicotinic acid hydrazide (Standard) ; Isonicotinic hydrazide (Standard)

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Autophagy; Bacterial; Mitophagy; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Autophagy; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/isoniazid-standard.html

Purity

99.77

Smiles

O=C(C1=CC=NC=C1)NN

Molecular Formula

C6H7N3O

Molecular Weight

137.14

Precautions

H302

References & Citations

[1]Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG) . J Biol Chem, 2009. 284 (11) : p. 7017-29.|[2]Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48 (8) : p. 3006-9.|[3]Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322 (5906) : p. 1392-5.|[4]Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200 (7) : p. 1136-43.