TNF-α (31-45), human (TFA)
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; NF-κB; TNF Receptor
Type
Peptides
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnf-alpha-31-45-human-tfa.html
Solubility
10 mM in H2O
Smiles
OC(C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(CNC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C69H122N26O22.xC2HF3O2
Molecular Weight
1667.87 (free acid)
References & Citations
[1]Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship (s) . Microsc Res Tech. 2000 Aug 1;50 (3) :184-95.|[2]Xi Rui, et al. RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma. Front Oncol. 2022 Jun 30:12:804439.|[3]Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22 (5) :2719.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NF-κB
Citation 01
Mol Med Rep. 2019 Oct;20 (4) :3565-3572.|Authorea. 2025 Feb 19.|Biocell. 2025 Apr 30.|Biomedicines. 2023 Dec 15;11 (12) :3314.|Cytotechnology. 2021 Oct;73 (5) :727-743.|Eur J Pharmacol. 2023 Dec 15:961:176193.|Front Oncol. 2022 Jun 30;12:804439.|Int Immunopharmacol. 2026 Jan 1;168 (Pt 1) :115856.|J Cell Commun Signal. 2025 Sep 21;19 (3) :e70045.|PLoS One. 2025 Apr 16;20 (4) :e0318311.
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