TNF-α (31-45), human (TFA)

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; NF-κB; TNF Receptor

Type

Peptides

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tnf-alpha-31-45-human-tfa.html

Solubility

10 mM in H2O

Smiles

OC(C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(CNC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C69H122N26O22.xC2HF3O2

Molecular Weight

1667.87 (free acid)

References & Citations

[1]Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship (s) . Microsc Res Tech. 2000 Aug 1;50 (3) :184-95.|[2]Xi Rui, et al. RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma. Front Oncol. 2022 Jun 30:12:804439.|[3]Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22 (5) :2719.