Namitecan
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.
Product Specifications
CAS Number
372105-27-6
Product Name Alternative
ST-1968
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/namitecan.html
Purity
98.03
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(/C=N/OCCN)C5=CC=CC=C5N=C4C3=C2)=O
Molecular Formula
C23H22N4O5
Molecular Weight
434.44
Precautions
H301
References & Citations
[1]De Cesare M, et al. Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number. Clin Cancer Res. 2014 Feb 15;20 (4) :995-1006.|[2]Zuco V, et al. Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma. Biochem Pharmacol. 2010 Feb 15;79 (4) :535-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Topo I
Available Sizes
Frequently Asked Questions
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