Namitecan

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

Product Specifications

CAS Number

[372105-27-6]

Product Name Alternative

ST-1968

UNSPSC

12352005

Hazard Statement

H301

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/namitecan.html

Purity

98.03

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(/C=N/OCCN)C5=CC=CC=C5N=C4C3=C2)=O

Molecular Formula

C23H22N4O5

Molecular Weight

434.44

Precautions

H301

References & Citations

[1]De Cesare M, et al. Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number. Clin Cancer Res. 2014 Feb 15;20 (4) :995-1006.|[2]Zuco V, et al. Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma. Biochem Pharmacol. 2010 Feb 15;79 (4) :535-41.