R (+) -Methylindazone

R (+) -Methylindazone (R (+) -IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R (+) -Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) [1][2][3].

Product Specifications

CAS Number

[54197-31-8]

Product Name Alternative

R (+) -IAA-94

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/r-plus-methylindazone.html

Purity

98.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC2=C(C([C@@](C)(C3CCCC3)C2)=O)C(Cl)=C1Cl

Molecular Formula

C17H18Cl2O4

Molecular Weight

357.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90 (6) :779-98.|[2]Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244 (4911) :1469-72.|[3]Xiaoqin Fan, et al. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol. 2015 Oct;47 (4) :1485-93.