Human KIR2DL4 / CD158d Protein, Fc Tag

Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) -AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP) -1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.