Human KIR2DL4 / CD158d Protein, Fc Tag
Human KIR2DL4, Fc Tag (KI4-H5255) is expressed from human 293 cells (HEK293) . It contains AA His 24 - His 242 (Accession # Q99706-1) .
Product Specifications
Background
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) -AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP) -1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q99706-1
Expression Region
His 24 - His 242
Host
HEK293
Target
KIR2DL4
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
50.5 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/KI4-H5255.pdf
Species
Human
Curated Selection
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