Pexacerfont
Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.
Product Specifications
CAS Number
459856-18-9
Product Name Alternative
BMS-562086
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Pexacerfont.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC[C@H](NC1=NC(C)=NC2=C(C3=CC=C(OC)N=C3C)C(C)=NN21)C
Molecular Formula
C18H24N6O
Molecular Weight
340.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou L, et al. In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug Metab Dispos. 2012 Jun;40 (6) :1093-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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