YSK 05

YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo[1].

Product Specifications

CAS Number

[1318793-78-0]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ysk-05.html

Purity

98.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCC(OCCCCCCCC/C=C\C/C=C\CCCCC)(OCCCCCCCC/C=C\C/C=C\CCCCC)CC1

Molecular Formula

C42H77NO2

Molecular Weight

628.07

Precautions

H225, H319

References & Citations

[1]Sato Y, et al. A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo. J Control Release. 2012 Nov 10;163 (3) :267-76.