CpG ODN 10101

CpG ODN 10101, a synthetic oligodeoxynucleotide (ODN), is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2 (VQLRIRVAVIRA-NH2) . CpG ODN 10101 induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 has antiviral and immunomodulatory properties that can influence chronic infection with HCV[1][2].

Product Specifications

CAS Number

[1234402-77-7]

Product Name Alternative

ODN 10101

UNSPSC

12352208

Target

HCV; Toll-like Receptor (TLR)

Type

Oligonucleotides

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cpg-odn-10101.html

Purity

99.44

Solubility

H2O : ≥ 25 mg/mL

Smiles

[CpGODN10101]

Molecular Weight

6702.37

References & Citations

[1]Jason Kindrachuk, et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine. 2009 Jul 23;27 (34) :4662-71.|[2]John G McHutchison, et al. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus. Hepatology. 2007 Nov;46 (5) :1341-9.