Glycolate oxidase-IN-1

Glycolate oxidase-IN-1 (compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) [1].

Product Specifications

CAS Number

[330977-65-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Glycolate Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glycolate-oxidase-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC(C2=CC=C(C=O)O2)=CC=C1O

Molecular Formula

C12H8O5

Molecular Weight

232.19

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]María Dolores Moya-Garzón, et al. Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem. 2018 Aug 23;61 (16) :7144-7167.