CDDO-EA
Product Specifications
Product Name Alternative
CDDO ethyl amide; TP319; RTA 405
UNSPSC Description
CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CDDO-EA.html
Purity
99.71
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(NCC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C
Molecular Weight
518.73
References & Citations
[1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12213/CDDO-EA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12213/CDDO-EA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
932730-51-3
Available Sizes
Curated Selection
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