CDDO-EA

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

Product Specifications

CAS Number

[932730-51-3]

Product Name Alternative

CDDO ethyl amide; TP319; RTA 405

UNSPSC

12352211

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CDDO-EA.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(NCC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C

Molecular Formula

C33H46N2O3

Molecular Weight

518.73

References & Citations

[1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51 (1) :88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67 (6) :2414-9.