Brexpiprazole-d8-1
Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[3].
Product Specifications
CAS Number
1427049-19-1
Product Name Alternative
OPC-34712-d8-1
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
96.48
Solubility
10 mM in DMSO
Smiles
O=C1C=CC2=CC=C(C=C2N1)OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(CC3)C4=C5C(SC=C5)=CC=C4
Molecular Formula
C25H19D8N3O2S
Molecular Weight
441.62
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor
Available Sizes
Frequently Asked Questions
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