Beloxepin

Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects[1][2].

Product Specifications

CAS Number

[135928-30-2]

Product Name Alternative

Org 4428; ADL 6906

UNSPSC

12352005

Hazard Statement

H302, H312, H317, H332, H334

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/beloxepin.html

Purity

98.04

Smiles

O[C@@]12[C@@](CN(CC2)C)([H])C3=CC=CC(C)=C3OC4=CC=CC=C41

Molecular Formula

C19H21NO2

Molecular Weight

295.38

Precautions

H302, H312, H317, H332, H334

References & Citations

[1]Lorenzo Di Cesare Mannelli, et al. α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. Mini Rev Med Chem. 2017;17 (2) :95-107.|[2]Craig T Hartrick. Noradrenergic reuptake inhibition in the treatment of pain. Expert Opin Investig Drugs. 2012 Dec;21 (12) :1827-34.