LDN-91946
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].
Product Specifications
CAS Number
[439946-22-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ldn-91946.html
Purity
98.04
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
OC(C1=CC2=C(SC(C(C3=CC=CC=C3)=O)=C2N)NC1=O)=O
Molecular Formula
C15H10N2O4S
Molecular Weight
314.32
Precautions
H315, H319, H335
References & Citations
[1]Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17 (13) :3729-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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