SC4453
Product Specifications
CAS Number
59712-21-9
UNSPSC Description
SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.
Target Antigen
Na+/K+ ATPase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sc4453.html
Smiles
O=C1OCC([C@H]2CCC3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O[C@@H]6C[C@@H]([C@@H]([C@@H](C)O6)O[C@@H]7C[C@@H]([C@@H]([C@@H](C)O7)O[C@@H]8C[C@@H]([C@@H]([C@@H](C)O8)O)O)O)O)CC[C@]5(C)[C@@]4([H])C[C@@H](OC(C)=O)[C@]23C)=C1
Molecular Weight
822.98
References & Citations
[1]INHIBITION BY DIGOXIN AND SC4453 OF (Na ÷ + K÷)-ATPase PREPARED FROM HUMAN HEART, GUINEA-PIG HEART AND GUINEA-PIG BRAIN
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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