Conantokin G

<strong>Conantokin G</strong> <strong>Catalog number:</strong> MDP0640 <strong>CAS Number: </strong>N/A <strong>Sequence: </strong>Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2 (Gla: L-γ-Carboxyglutamic acid) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 2264 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Klein RC, Galdzicki Z, Castellino FJ. Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons Neuropharmacology. 1999 Dec;38(12):1819-29. 2: Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy J Biol Chem. 1997 Jan 24;272(4):2291-9. 3: Ragnarsson L, Yasuda T, Lewis RJ, Dodd PR, Adams DJ. NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G J Neurochem. 2006 Jan;96(1):283-91. 4: Balsara R, Dang A, Donahue DL, Snow T, Castellino FJ. Conantokin-G attenuates detrimental effects of NMDAR hyperactivity in an ischemic rat model of stroke PLoS One. 2015 Mar 30;10(3):e0122840. 5: Blandl T, Warder SE, Prorok M, Castellino FJ. Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T J Pept Res. 1999 Apr;53(4):453-64. 6: Donevan SD, McCabe RT. Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors Mol Pharmacol. 2000 Sep;58(3):614-23. 7: Klein RC, Castellino FJ. Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T Neurosci Lett. 1999 Oct 8;273(3):171-4. 8: Prorok M, Castellino FJ. Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T J Biol Chem. 1998 Jul 31;273(31):19573-8. 9: Chandler P, Pennington M, Maccecchini ML, Nashed NT, Skolnick P. Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist J Biol Chem. 1993 Aug 15;268(23):17173-8. <a href="https://pubmed.ncbi.nlm.nih.gov/1358659">10: Hammerland LG, Olivera BM, Yoshikami D. Conantokin-G selectively inhibits N-methyl-D-aspartate-induced currents in Xenopus oocytes injected with mouse brain mRNA Eur J Pharmacol. 1992 Jul 1;226(3):239-44. </a> <br><strong>Products Related to Conantokin G can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>