Dihydrokavain
Dihydrokavain (7,8-Dihydrokawain) is a natural kavalactone compound. Dihydrokavain inhibits COX-1, COX-2, CYP2C9 (IC50 = 130.95 μM), CYP2C19 (IC50 = 10.05 μM) and CYP3A4 (IC50 = 78.59 μM) . Dihydrokavain reduces TNFα secretion. Dihydrokavain shows analgesic and anxiolytic effects[1][2][3][4][5].
Product Specifications
CAS Number
587-63-3
Product Name Alternative
7,8-Dihydrokawain; 7,8-Dihydrokavain; Marindinin
UNSPSC
12352005
Hazard Statement
H302
Target
COX; Cytochrome P450
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Dihydrokavain.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(OC)C[C@H](CCC2=CC=CC=C2)O1
Molecular Formula
C14H16O3
Molecular Weight
232.28
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; CYP2C19; CYP2C9; CYP3A4
Available Sizes
Frequently Asked Questions
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