Protoveratrine A

Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases[1].

Product Specifications

CAS Number

[143-57-7]

Product Name Alternative

NSC 7526; Protalba; Protoveratrin

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Glutamate Dehydrogenase (GLDH)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/protoveratrine-a.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]34[C@]([C@H](OC(C)=O)[C@H](OC(C)=O)[C@]1([H])[C@@](O)([C@@H](OC([C@@](C)(O)CC)=O)CC2)O4)([H])[C@@]5(O)[C@@]([C@@]6([H])[C@]([C@](O)([C@@]7([H])N(C[C@@H](C)CC7)C6)C)([H])[C@@H](O)[C@@H]5OC([C@H](C)CC)=O)([H])C3

Molecular Formula

C41H63NO14

Molecular Weight

793.94

Precautions

H300+H310+H330

References & Citations

[1]B M WINER, et al. Comparative studies of protoveratrine A and protoveratrine B intravenously in hypertensive man. Circulation. 1960 Dec;22:1074-82.|[2]Huger F P, et al. Tetrodotoxin inhibition in vitro of protoveratrine A-activated glutamate decarboxylase in synaptosomes[J]. Biochemical Pharmacology, 1980, 29 (21) : 3034-3036.