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Diphenhydramine-d6 (hydrochloride)

Diphenhydramine-d6 (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2].

Product Specifications

CAS Number

[1189986-72-8]

UNSPSC

12352005

Target

Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Endocrinology

Purity

98.61

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)

Smiles

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Molecular Formula

C17H16D6ClNO

Molecular Weight

297.85

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10 (5) :350-380.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

H1 Receptor

Available Sizes

Curated Selection

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