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C5a Receptor agonist, W5Cha

C5a Receptor agonist, W5Cha (Peptide 1) is a selective complement C5a receptor (C5aR) agonist (EC50=0.2 μM), a hexapeptide derived from the C-terminus of C5a with specific amino acid modifications. C5a Receptor agonist, W5Cha is able to interact with the Arg-206 site of the C5a receptor through its C-terminal arginine, thereby activating the receptor[1].

Product Specifications

CAS Number

[144555-23-7]

UNSPSC

12352209

Target

Complement System

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/c5a-receptor-agonist-mouse-human.html

Purity

99.50

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@H](C(O)=O)NC([C@H](CC1CCCCC1)NC([C@@H](CC2CCCCC2)NC([C@H]3N(CCC3)C([C@H](CCCCN)NC([C@@H](NC)CC4=CC=CC=C4)=O)=O)=O)=O)=O

Molecular Formula

C45H74N10O7

Molecular Weight

867.13

References & Citations

[1]DeMartino, et al. Arginine 206 of the C5a Receptor Is Critical for Ligand Recognition and Receptor Activation by C-terminal Hexapeptide Analogs. Journal of Biological Chemistry 270.27 (1995) : 15966-15969.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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