T-3775440 hydrochloride
T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.
Product Specifications
CAS Number
[1422535-52-1]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/T-3775440_hydrochloride.html
Purity
99.13
Solubility
DMSO : ≥ 30.18 mg/mL|H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C([C@@H]2C[C@H]2NCC3CC3)C=C1)C4=CN(C)N=C4.Cl
Molecular Formula
C18H23ClN4O
Molecular Weight
346.85
References & Citations
[1]Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16 (2) :273-284.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1
Available Sizes
Curated Selection
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