Emapalumab
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) [1].
Product Specifications
CAS Number
[1709815-23-5]
Product Name Alternative
NI-0501
UNSPSC
12352203
Target
IFNAR
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/emapalumab.html
Purity
98.86
Solubility
10 mM in DMSO
Smiles
[Emapalumab]
Molecular Weight
(145.22 kDa)
References & Citations
[1]Vallurupalli M, et, al. Emapalumab for the treatment of relapsed/refractory hemophagocytic lymphohistiocytosis. Blood. 2019 Nov 21;134 (21) :1783-1786.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Available Sizes
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